Axonal regeneration and motor neuron survival after microsurgical nerve reconstruction
نویسندگان
چکیده
منابع مشابه
Effects of Valproic Acid on Axonal Regeneration and Recovery of Motor Function after Peripheral Nerve Injury in the Rat
Background: Valproic acid (VPA) is used to be an effective anti-epileptic drug and mood stabilizer. It has recently been demonstrated that VPA could promote neurite outgrowth, activate the extracellular signal regulated kinase pathway, and increases bcl-2 and growth cone-associated protein 43 levels in spinal cord. In the present research we demonstrate the effect of VPA on peripheral nerve r...
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Axon can’t regenerate after central nervous system injury because of myelin-associated protein exerting its effects through the paired immunoglobulin like receptor (PirB). In our study, axon regeneration of retinal ganglion cells (RGCs) after optic nerve (ON) crush was investigated both in vivo and in vitro in rat after PirBsiRNA transfection. The eyes transfected with AAV-PirBsiRNA were as exp...
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We subjected rats to either partial midcervical or complete upper thoracic spinal cord transections and examined whether combinatorial treatments support motor axonal regeneration into and beyond the lesion. Subjects received cAMP injections into brainstem reticular motor neurons to stimulate their endogenous growth state, bone marrow stromal cell grafts in lesion sites to provide permissive ma...
متن کاملeffects of valproic acid on axonal regeneration and recovery of motor function after peripheral nerve injury in the rat
background: valproic acid (vpa) is used to be an effective anti-epileptic drug and mood stabilizer. it has recently been demonstrated that vpa could promote neurite outgrowth, activate the extracellular signal regulated kinase pathway, and increases bcl-2 and growth cone-associated protein 43 levels in spinal cord. in the present research we demonstrate the effect of vpa on peripheral nerve r...
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Introduction: The peripheral nervous system is remarkable in its ability to regenerate after injury because of a local permissive environment and activation of the neuronal intrinsic growth capacity. Local induction of inflammatory cytokines, which are produced by macrophages and Schwann cells, plays a crucial role in controlling Wallerian degeneration (WD) and nerve regeneration (1). Tumor nec...
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ژورنال
عنوان ژورنال: Microsurgery
سال: 2012
ISSN: 0738-1085
DOI: 10.1002/micr.22036